Synthesis andIn VitroAntibacterial Activity of New 2-(1-Methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles | Zendy

Bahram Letafat | Zendy; Negar Mohammadhosseini | Zendy; Ali Asadipour | Zendy; Alireza Foroumadi | Zendy

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Synthesis andIn VitroAntibacterial Activity of New 2-(1-Methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles

Author(s) -

Bahram Letafat,

Negar Mohammadhosseini,

Ali Asadipour,

Alireza Foroumadi

Publication year - 2011

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2011/642071

Subject(s) - staphylococcus epidermidis , bacillus subtilis , antibacterial activity , thiadiazoles , staphylococcus aureus , bacteria , gram , chemistry , gram positive bacteria , residue (chemistry) , antimicrobial , microbiology and biotechnology , nitro , organic chemistry , biology , genetics , alkyl

In the present study we report the synthesis and antibacterial activity of a new series 2-(1-methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles (6a-c). Compounds 6a-c were tested in vitro by the conventional agar dilution method against a panel of microorganisms including gram-negative and gram-positive bacteria. Compound 6b with 5-(5-nitrofuran-2-yl)-residue on 1,3,4-thiadiazole scaffold have shown promising antibacterial activities against gram-positive bacteria including Staphylococcus aureus, Staphylococcus epidermidis and Bacillus subtilis.

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