Neurturin Evokes MAPK-Dependent Upregulation of Egr4 and KCC2 in Developing Neurons | Zendy

Anastasia Ludwig | Zendy; Pavel Uvarov | Zendy; Christophe Pellegrino | Zendy; Judith Thomas-Crusells | Zendy; Sebastian Schuchmann | Zendy; Märt Saarma | Zendy; Matti S. Airaksinen | Zendy; Claudio Rivera | Zendy

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Neurturin Evokes MAPK-Dependent Upregulation of Egr4 and KCC2 in Developing Neurons

Author(s) -

Anastasia Ludwig,

Pavel Uvarov,

Christophe Pellegrino,

Judith Thomas-Crusells,

Sebastian Schuchmann,

Märt Saarma,

Matti S. Airaksinen,

Claudio Rivera

Publication year - 2011

Publication title -

neural plasticity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.288

H-Index - 68

eISSN - 2090-5904

pISSN - 1687-5443

DOI - 10.1155/2011/641248

Subject(s) - downregulation and upregulation , neurturin , microbiology and biotechnology , mapk/erk pathway , neuroscience , neurotrophic factors , transcription factor , chemistry , biology , glial cell line derived neurotrophic factor , signal transduction , receptor , biochemistry , gene

The K-Cl cotransporter KCC2 plays a crucial role in the functional development of GABA(A)-mediated responses rendering GABA hyperpolarizing in adult neurons. We have previously shown that BDNF upregulates KCC2 in immature neurons through the transcription factor Egr4. The effect of BDNF on Egr4 and KCC2 was shown to be dependent on the activation of ERK1/2. Here we demonstrate that the trophic factor neurturin can also trigger Egr4 expression and upregulate KCC2 in an ERK1/2-dependent manner. These results show that Egr4 is an important component in the mechanism for trophic factor-mediated upregulation of KCC2 in immature neurons involving the activation of specific intracellular pathways common to BDNF and Neurturin.

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