Clinical Pharmacology of Chemotherapy Agents in Older People with Cancer | Zendy

Xiaoye He | Zendy; Stephen Clarke | Zendy; Andrew J. McLachlan | Zendy

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Clinical Pharmacology of Chemotherapy Agents in Older People with Cancer

Author(s) -

Xiaoye He,

Stephen Clarke,

Andrew J. McLachlan

Publication year - 2011

Publication title -

current gerontology and geriatrics research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.564

H-Index - 28

eISSN - 1687-7071

pISSN - 1687-7063

DOI - 10.1155/2011/628670

Subject(s) - medicine , cancer , clinical pharmacology , chemotherapy , cancer chemotherapy , drug , concomitant , cancer incidence , cancer treatment , geriatric oncology , intensive care medicine , oncology , pharmacology

Populations around the world are aging, and the associated increase in cancer incidence has led to the recognition of the importance of geriatric oncology. Chronological age is a poor determinant of pharmacological response to cancer chemotherapy agents. Age-associated changes in physiology and organ function have a significant impact on the clinical pharmacology of cancer chemotherapy agents used in cancer treatment. Altered response to medicines in older people is a consequence of changes in body composition, organ function, concomitant pathophysiology, multiple medications, genetic determinants of drug response, and patient's clinical status. These issues highlight the need to individualize the management of cancer in the older people with consideration of age-related changes in the clinical pharmacology of cancer drugs, analgesics, and adjunctive therapies.

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