Direct Immunosensor Design Based on the Electrochemical Reduction of 4-((4-Nitrophenyl)ethynyl)benzenethiol Monolayers | Zendy

Dwight A. Williams | Zendy; Wraegen A. M. Williams | Zendy; Melissa C. Rhoten | Zendy; Charlene D. Crawley | Zendy; Suzanne M. Ruder | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Direct Immunosensor Design Based on the Electrochemical Reduction of 4-((4-Nitrophenyl)ethynyl)benzenethiol Monolayers

Author(s) -

Dwight A. Williams,

Wraegen A. M. Williams,

Melissa C. Rhoten,

Charlene D. Crawley,

Suzanne M. Ruder

Publication year - 2011

Publication title -

journal of sensors

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.399

H-Index - 43

eISSN - 1687-7268

pISSN - 1687-725X

DOI - 10.1155/2011/609758

Subject(s) - hydroxylamine , electrochemistry , monolayer , electrode , chemistry , nitrobenzene , covalent bond , cyclic voltammetry , combinatorial chemistry , self assembled monolayer , organic chemistry , catalysis , biochemistry

The synthesis and characterization of novel N-arylhydroxylamine-based molecular wires are described for use in the site-directed covalent immobilization of whole IgG antibodies onto gold electrode surfaces. The hydroxylamine, electrochemically generated in situ from reduction of the corresponding nitrobenzene, is stable under a wide range of solution conditions and reacts selectively with carbohydrate away from the antibody-binding site to allow the development of immunosensors with maximal activity. Cyclic voltammetric responses have shown a direct correlation between the structure and length of the molecular wire and its stability and concentration at the electrode surface

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research