Synthesis of Some More Fluorine Heterocyclic Nitrogen Systems Derived From Sulfa Drugs as Photochemical Probe Agents for Inhibition of Vitiligo Disease-Part I | Zendy

Reda M. AbdelRahman | Zendy; Mohammad S.I. Makki | Zendy; Wafa A. Bawazir | Zendy

Open Access

Synthesis of Some More Fluorine Heterocyclic Nitrogen Systems Derived From Sulfa Drugs as Photochemical Probe Agents for Inhibition of Vitiligo Disease-Part I

Author(s) -

Reda M. AbdelRahman,

Mohammad S.I. Makki,

Wafa A. Bawazir

Publication year - 2010

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2011/586063

Subject(s) - chemistry , vitiligo , photochromism , pyrazoline , fluorine , imidazole , triazole , photochemistry , benzothiazole , sulfur , combinatorial chemistry , organic chemistry , dermatology , medicine

Some more new bioactive fluorine heterocyclic systems containing sulfur and nitrogen as five-membered rings: pyrazoline, imidazole, imidazolopyrimidine, thiazolidinone and 1,2,4-triazole derivatives (3-13) have been synthetically derived from the interaction of sulfa drugs with fluorine aromatic aldehyde and/or hexa fluoroacetic anhydride followed by heterocyclization reactions. Former structures of the targets have been deduced upon the help of elemental and spectral data.. Compounds 7a-f, 10c and 13 could be used as photochemical probe agents for inhibition of Vitiligo diseases, in compare with Nystatin and Nalidixic acid.

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