Antimycobacterial Activity of Some Synthesized Fluorinated Benzothiazolo Imidazole Compounds
Author(s) -
B. S. Sathe,
E. Jaychandran,
G. M. Sreenivasa,
V. A. Jagtap
Publication year - 2010
Publication title -
journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2090-9063
pISSN - 2090-9071
DOI - 10.1155/2011/581429
Subject(s) - antimycobacterial , imidazole , chemistry , combinatorial chemistry , organic chemistry , medicine , tuberculosis , mycobacterium tuberculosis , pathology
4-Fluoro-3-chloroanilline treated with potassium thiocyanate in presence of glacial acetic acid and bromine was converted into 2-amino-6-fluoro-7-chlorobenzothiazole, resulting into 2-amino benzothiazole. The synthesized compound in presence of 2-phenyl-4-benzylidine-5-oxazolinone refluxed in pyridine to obtain 2-(2-phenyl-4-benzylidenyl-5-oxo-imidazolin-1-yl amino)-6-fluoro-7-substituted(1,3)benzothiazoles. The above said compound was treated with ortho, meta and para nitroanillines, ortho, meta, para chloroanillines, morpholino, piperazine, diphenylamine in the presence of DMF to obtain different derivatives. Some compounds showed promising anti-microbial activity
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