Characterization of Ex Vivo Expanded Tumor Infiltrating Lymphocytes from Patients with Malignant Melanoma for Clinical Application | Zendy

Niels Junker | Zendy; Per thor Straten | Zendy; Mads Hald Andersen | Zendy; Inge Marie Svane | Zendy

Open Access

Characterization of Ex Vivo Expanded Tumor Infiltrating Lymphocytes from Patients with Malignant Melanoma for Clinical Application

Author(s) -

Niels Junker,

Per thor Straten,

Mads Hald Andersen,

Inge Marie Svane

Publication year - 2011

Publication title -

journal of skin cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.309

H-Index - 10

eISSN - 2090-2905

pISSN - 2090-2913

DOI - 10.1155/2011/574695

Subject(s) - melanoma , medicine , tumor infiltrating lymphocytes , adoptive cell transfer , ex vivo , effector , antigen , immunotherapy , clinical trial , tumor cells , in vivo , metastatic melanoma , pathology , cancer research , immunology , t cell , immune system , biology , microbiology and biotechnology

Clinical trials of adoptive transfer of autologous tumor infiltrating lymphocytes (TILs) to patients with advanced malignant melanoma have shown remarkable results with objective clinical responses in 50% of the treated patients. In order to initiate a clinical trial in melanoma, we have established a method for expanding TILs to clinical relevant quantities in two steps with in 8 weeks. Further characterization of expanded TILs revealed an oligoclonal composition of T-cells with an effector memory like phenotype. When autologous tumor was available, TILs showed specific activity in all patients tested. TIL cultures contained specificity towards tumor cells as well as peptides derived from tumor-associated antigens (TAAs) during expansion procedures.

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