Tuberous Sclerosis Complex Associated with Papillary Serous Carcinoma of the Peritoneum, Lymphangioleiomyomatosis, and Angiomyolipoma | Zendy

Tomihiro Wakamiya | Zendy; Yasuo Sugita | Zendy; Mariko Hashiguchi | Zendy; Tsuyoshi Iwasaka | Zendy; Osamu Tokunaga | Zendy

Open Access

Tuberous Sclerosis Complex Associated with Papillary Serous Carcinoma of the Peritoneum, Lymphangioleiomyomatosis, and Angiomyolipoma

Author(s) -

Tomihiro Wakamiya,

Yasuo Sugita,

Mariko Hashiguchi,

Tsuyoshi Iwasaka,

Osamu Tokunaga

Publication year - 2011

Publication title -

case reports in pathology

Language(s) - English

Resource type - Journals

eISSN - 2090-6781

pISSN - 2090-679X

DOI - 10.1155/2011/564260

Subject(s) - lymphangioleiomyomatosis , pathology , tuberous sclerosis , medicine , calretinin , angiomyolipoma , carcinoembryonic antigen , serous fluid , immunohistochemistry , peritoneum , cancer , kidney

Tuberous sclerosis complex (TSC) is associated with benign and malignant tumors, including lymphangioleiomyomatosis (LAM) and angiomyolipoma (AML). We herein describe the TSC case of a 50-year-old woman having a papillary serous carcinoma of the peritoneum (PSCP), LAM, and AML. On microscopic examination, the PSCP cells showed a cuboidal to columnar shape, proliferated into the papillae, and infiltrated into the peritoneal cavity and anterior thoracic wall. On immunohistochemical evaluation, the tumor cells were positive for epithelial membrane antigen, human epidermal cytokeratins, and progesterone receptor, but negative for calretinin, carcinoembryonic antigen, MCF-7 cell line (Ber-EP4), and estrogen receptor.

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