Evaluation ofIn VitroAnti-inflammatory Activity of Azomethines of Aryl Oxazoles
Author(s) -
V. Niraimathi,
A. Suresh,
T. Sree Latha
Publication year - 2011
Publication title -
journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2090-9063
pISSN - 2090-9071
DOI - 10.1155/2011/561759
Subject(s) - hemolysis , in vitro , diclofenac sodium , erythrocyte membrane , tonicity , membrane , chemistry , aryl , inflammation , cationic polymerization , pharmacology , biochemistry , organic chemistry , chromatography , biology , immunology , alkyl
Ability to inhibit erythrocyte hemolysis is often used as a characteristic of the membrane stabilising action of chemical compounds. Azomethines of aryl oxazoles were evaluated for anti-inflammatory by in vitro hemolytic membrane stabilising study. The effect of inflammation condition was studied on erythrocyte exposed to hypotonic solution. In this in vitro method the membrane stabilising action leads to anti-inflammatory activity and was compared with that produced by diclofenac sodium as the reference standard. Results of the evaluation indicate that the synthesised compounds found to exhibit membrane stabilising activity
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