Method Development and Validation for Determination of Voglibose in Tablet Formulation Using LC-MS/MS | Zendy

Mithlesh Rajput | Zendy; Meenakshi Dahiya | Zendy; Premlata Kumari | Zendy; Kamini Kalra | Zendy; Manjeet Aggarwal | Zendy; Rakesh Kumar Khandal | Zendy

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Method Development and Validation for Determination of Voglibose in Tablet Formulation Using LC-MS/MS

Author(s) -

Mithlesh Rajput,

Meenakshi Dahiya,

Premlata Kumari,

Kamini Kalra,

Manjeet Aggarwal,

Rakesh Kumar Khandal

Publication year - 2010

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2011/531762

Subject(s) - chromatography , chemistry , pharmacology , medicine

Voglibose is a potent α glucosidase inhibitor, used for the treatment of diabetes mellitus. For quantitative determination of voglibose in pharmaceutical formulations of low doses, simple, sensitive, accurate and precise LC-MS/MS method using electrospray ionization in positive mode was developed and validated. The method was found linear in the concentration range of 25.0-1200 ηg/mL with a correlation coefficient of 0.9998. The limit of detection (LOD) of the method was found to be 1.5 ηg/mL and limit of quantitation (LOQ) was achieved at 3.0 ηg/mL. The recoveries of voglibose from spiked samples at different concentration levels were found in the range of 98-102%. The proposed method was found suitable for quantitation of voglibose and for the determination of uniformity of content of the dosage units of the tablet formulations.

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