Application of Flow Focusing to the Break-Up of a Magnetite Suspension Jet for the Production of Paramagnetic Microparticles | Zendy

Lucía MartínBanderas | Zendy; Román GonzálezPrieto | Zendy; Alfonso RodríguezGil | Zendy; Mercedes Fernández Arévalo | Zendy; María Victoria Flores | Zendy; Sebastián Chávez | Zendy; Alfonso M. GañánCalvo | Zendy

Open Access

Application of Flow Focusing to the Break-Up of a Magnetite Suspension Jet for the Production of Paramagnetic Microparticles

Author(s) -

Lucía MartínBanderas,

Román GonzálezPrieto,

Alfonso RodríguezGil,

Mercedes Fernández Arévalo,

María Victoria Flores,

Sebastián Chávez,

Alfonso M. GañánCalvo

Publication year - 2010

Publication title -

journal of nanomaterials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.463

H-Index - 66

eISSN - 1687-4129

pISSN - 1687-4110

DOI - 10.1155/2011/527437

Subject(s) - materials science , paramagnetism , suspension (topology) , biomolecule , magnetite , magnet , covalent bond , polydimethylsiloxane , nanotechnology , jet (fluid) , chemical engineering , organic chemistry , chemistry , mechanical engineering , physics , mathematics , homotopy , pure mathematics , engineering , metallurgy , thermodynamics , quantum mechanics

Paramagnetic particles offer an extensive improvement in the magnetic separation or purification of a wide variety of protein molecules. Most commercial paramagnetic particles are synthesized by laborious and costly procedures. A straightforward production of paramagnetic microparticles with homogeneous and selectable sizes using flow focusing (FF) technology is described in this work. The development of an initial formulation of a stable iron oxide suspension compatible with the FF requirements is also reported. The obtained particles, below 10 microns in diameter and presenting smooth and reactive surface, were codified with an organic fluorophore and showed excellent properties for covalent attachment of biomolecules such as proteins and its subsequent recognition by flow cytometry. Furthermore, particles with suitable magnetite content resulted as well-suited for commercial magnet separators for these purposes

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