Apoptosis Modulation as a Promising Target for Treatment of Systemic Sclerosis | Zendy

Stéphane Chabaud | Zendy; Véronique Moulin | Zendy

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Apoptosis Modulation as a Promising Target for Treatment of Systemic Sclerosis

Author(s) -

Stéphane Chabaud,

Véronique Moulin

Publication year - 2011

Publication title -

international journal of rheumatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.8

H-Index - 33

eISSN - 1687-9279

pISSN - 1687-9260

DOI - 10.1155/2011/495792

Subject(s) - apoptosis , medicine , fibrosis , immune system , mechanism (biology) , disease , scleroderma (fungus) , multiple sclerosis , function (biology) , immune modulation , immunology , cancer research , pathology , bioinformatics , neuroscience , biology , microbiology and biotechnology , biochemistry , philosophy , epistemology , inoculation

Diffuse systemic sclerosis (SSc) is a fatal autoimmune disease characterized by an excessive ECM deposition inducing a loss of function of skin and internal organs. Apoptosis is a key mechanism involved in all the stages of the disease: vascular damage, immune dysfunction, and fibrosis. The purpose of this paper is to gather new findings in apoptosis related to SSc, to highlight relations between apoptosis and fibrosis, and to identify new therapeutic targets.

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