Different Adipose Depots: Their Role in the Development of Metabolic Syndrome and Mitochondrial Response to Hypolipidemic Agents | Zendy

Bodil Bjørndal | Zendy; Lena Burri | Zendy; Vidar Staalesen | Zendy; Jon Skorve | Zendy; Rolf K. Berge | Zendy

Open Access

Different Adipose Depots: Their Role in the Development of Metabolic Syndrome and Mitochondrial Response to Hypolipidemic Agents

Author(s) -

Bodil Bjørndal,

Lena Burri,

Vidar Staalesen,

Jon Skorve,

Rolf K. Berge

Publication year - 2011

Publication title -

journal of obesity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.756

H-Index - 53

eISSN - 2090-0716

pISSN - 2090-0708

DOI - 10.1155/2011/490650

Subject(s) - adipose tissue , adipokine , lipolysis , medicine , insulin resistance , metabolic syndrome , endocrinology , obesity , diabetes mellitus , mitochondrion , bioinformatics , biology , microbiology and biotechnology

Adipose tissue metabolism is closely linked to insulin resistance, and differential fat distributions are associated with disorders like hypertension, diabetes, and cardiovascular disease. Adipose tissues vary in their impact on metabolic risk due to diverse gene expression profiles, leading to differences in lipolysis and in the production and release of adipokines and cytokines, thereby affecting the function of other tissues. In this paper, the roles of the various adipose tissues in obesity are summarized, with particular focus on mitochondrial function. In addition, we discuss how a functionally mitochondrial-targeted compound, the modified fatty acid tetradecylthioacetic acid (TTA), can influence mitochondrial function and decrease the size of specific fat depots

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