Synthesis and Antimicrobial Activity ofSome New Thioether Derivatives of Quinoxaline | Zendy

Davinder Singh | Zendy; Syed Riaz Hashim | Zendy; R G Singhal | Zendy

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Synthesis and Antimicrobial Activity ofSome New Thioether Derivatives of Quinoxaline

Author(s) -

Davinder Singh,

Syed Riaz Hashim,

R G Singhal

Publication year - 2010

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2011/482831

Subject(s) - quinoxaline , thioether , antimicrobial , chemistry , combinatorial chemistry , organic chemistry

2-Chloro-3-methylquinoxaline was selected as nucleus around which the molecular manipulations were carried out to get new compounds expected to possess better anti microbial activity. Various quinoxaline derivatives have been synthesized by replacing the chlorine at C-2 with a thioether linkage, which in turn attached to 2-(N-(substituted phenyl)acetamides. The synthesized compounds (5) were tested for their antimicrobial activity. Compounds 5b, 5c, 5d and 5i were found most active (comparable to the standard antibacterial Ciprofloxacin) amongst them. The structure of the compounds was confirmed on the basis of their spectral data

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