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Rats(r) with secondary hyperparathyroidism were studied to define the relationship between vitamin D metabolites and rPTH levels measured by 3 different rat ELISAs. Controls and renal failure (RF) rats were on a normal diet, while 2 groups on a low-calcium (-Ca) or a vitamin D-deficient (-D) diet. RF was induced surgically. Mild RF rats had normal calcium and 25(OH)D but reduced 1,25(OH) 2 D levels ( P  < .001) with a 2.5-fold increased in rPTH ( P  < .001). Severe RF rats and those on a -Ca or -D diet had reduced calcium ( P  < .01) and 25(OH)D levels ( P  < .05), with rPTH increased by 2 (-Ca diet;  P  < .05), 4 (-D diet;  P  < .001), and 20-folds (RF;  P  < .001) while 1,25(OH) 2 D was high (-Ca diet:  P  < .001) or low (-D diet, RF:  P  < .001). 25(OH)D and 1,25(OH) 2 D were positively and negatively related on the -Ca and -D diets, respectively.  rPTH molecular forms behaved as expected in RF and on -Ca diet, but not on -D diet with more C-rPTH fragments when less were expected. This may be related to the short-time course of this study compared to prior studies.

international journal of endocrinology

Influence of Secondary Hyperparathyroidism Induced by Low Dietary Calcium, Vitamin D Deficiency, and Renal Failure on Circulating Rat PTH Molecular Forms