Carbon Nanotubes/Gold Nanoparticles Composite Film for the Construction of a Novel Amperometric Choline Biosensor | Zendy

Baoyan Wu | Zendy; Zhongmin Ou | Zendy; Xiaojuan Ju | Zendy; Shihua Hou | Zendy

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Carbon Nanotubes/Gold Nanoparticles Composite Film for the Construction of a Novel Amperometric Choline Biosensor

Author(s) -

Baoyan Wu,

Zhongmin Ou,

Xiaojuan Ju,

Shihua Hou

Publication year - 2011

Publication title -

journal of nanomaterials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.463

H-Index - 66

eISSN - 1687-4129

pISSN - 1687-4110

DOI - 10.1155/2011/464919

Subject(s) - choline oxidase , materials science , biosensor , colloidal gold , amperometry , detection limit , carbon nanotube , platinum nanoparticles , electrode , aqueous solution , chemical engineering , nanoparticle , choline , nanotechnology , nuclear chemistry , electrochemistry , chromatography , organic chemistry , chemistry , engineering , acetylcholinesterase , enzyme , biochemistry

This study develops a facile method to fabricate a novel choline biosensor based on multiwalled carbon nanotubes (MWCNTs) and gold nanoparticles (AuNPs). Chitosan, a natural biocompatible polymer, was used to solubilize MWCNTs for constructing the aqueous Chit-MWCNTs solution. Then Chit-MWCNTs were first dropped on the surface of a cleaned platinum electrode. Finally, a thiolated silica sol containing AuNPs and choline oxidase (ChOx) was immobilized on the surface of the Chit-MWCNTs-modified electrode. The MWCNTs/AuNPs/Pt electrode showed excellent electrocatalytic activity for choline. The resulting choline biosensor showed high sensitivity of choline (3.56 μA/mM), and wide linear range from 0.05 to 0.8 mM with the detection limit of 15 μM. In addition, good reproducibility and stability were obtained

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