TFE3 Translocation-Associated Renal Cell Carcinoma Presenting as Avascular Necrosis of the Femur in a 19-Year-Old Patient: Case Report and Review of the Literature | Zendy

Thomas Nelius | Zendy; Ihsan Al-Khalil | Zendy; Jonathan S. Vordermark | Zendy; K. Rinard-Holden | Zendy; Taylor L. Cammack | Zendy; Viviane Mamlok | Zendy; Stéphanie Filleur | Zendy

Open Access

TFE3 Translocation-Associated Renal Cell Carcinoma Presenting as Avascular Necrosis of the Femur in a 19-Year-Old Patient: Case Report and Review of the Literature

Author(s) -

Thomas Nelius,

Ihsan Al-Khalil,

Jonathan S. Vordermark,

K. Rinard-Holden,

Taylor L. Cammack,

Viviane Mamlok,

Stéphanie Filleur

Publication year - 2011

Publication title -

case reports in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.2

H-Index - 20

eISSN - 1687-9627

pISSN - 1687-9635

DOI - 10.1155/2011/432917

Subject(s) - medicine , avascular necrosis , renal cell carcinoma , malignancy , chromosomal translocation , cancer , tfe3 , kidney , necrosis , carcinoma , pathology , surgery , femoral head , gene expression , promoter , biochemistry , gene , chemistry

In the United States, renal cell carcinoma (RCC) accounts for approximately 3% of adult malignancies and 90–95% of all neoplasms arising from the kidney. According to the National Cancer Institute, 58 240 new cases and 13 040 deaths from renal cancer will occur in 2010. RCC usually occurs in older adults between the ages of 50 and 70 and is rare in young adults and children. We describe a case of a TFE3 translocation-associated RCC in a 19-year-old patient presenting as avascular necrosis of the femur. Due to the rarity of this malignancy, we present this case including a review of the existing literature relative to diagnosis and treatment.

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