Chlamydia trachomatisImmune Evasion via Downregulation of MHC Class I Surface Expression Involves Direct and Indirect Mechanisms | Zendy

Joyce A. Ibana | Zendy; Danny J. Schust | Zendy; Jun Sugimoto | Zendy; Takeshi Nagamatsu | Zendy; Sheila Greene | Zendy; Alison J. Quayle | Zendy

Open Access

Chlamydia trachomatisImmune Evasion via Downregulation of MHC Class I Surface Expression Involves Direct and Indirect Mechanisms

Author(s) -

Joyce A. Ibana,

Danny J. Schust,

Jun Sugimoto,

Takeshi Nagamatsu,

Sheila Greene,

Alison J. Quayle

Publication year - 2011

Publication title -

infectious diseases in obstetrics and gynecology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.656

H-Index - 48

eISSN - 1098-0997

pISSN - 1064-7449

DOI - 10.1155/2011/420905

Subject(s) - chlamydia trachomatis , cd1d , mhc class i , immunology , biology , major histocompatibility complex , immune system , downregulation and upregulation , population , antigen , mhc class ii , virology , t cell , medicine , gene , genetics , t cell receptor , environmental health

Genital C. trachomatis infections typically last for many months in women. This has been attributed to several strategies by which C. trachomatis evades immune detection, including well-described methods by which C. trachomatis decreases the cell surface expression of the antigen presenting molecules major histocompatibility complex (MHC) class I, MHC class II, and CD1d in infected genital epithelial cells. We have harnessed new methods that allow for separate evaluation of infected and uninfected cells within a mixed population of chlamydia-infected endocervical epithelial cells to demonstrate that MHC class I downregulation in the presence of C. trachomatis is mediated by direct and indirect (soluble) factors. Such indirect mechanisms may aid in priming surrounding cells for more rapid immune evasion upon pathogen entry and help promote unfettered spread of C. trachomatis genital infections.

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