Open AccessA Camera Phone Localised Surface Plasmon Biosensing Platform towards Low-Cost Label-Free Diagnostic Testing
Author(s) -
Philip J. R. Roche,
Sandrine Filion-Côté,
Maurice C.-K. Cheung,
Vamsy P. Chodavarapu,
Andrew G. Kirk
Publication year - 2011
Publication title -
journal of sensors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.399
H-Index - 43
eISSN - 1687-7268
pISSN - 1687-725X
DOI - 10.1155/2011/406425
Subject(s) - surface plasmon resonance , sensitivity (control systems) , spectrometer , materials science , phone , biosensor , colloidal gold , point of care , nanotechnology , computer science , computer hardware , nanoparticle , electronic engineering , optics , engineering , physics , medicine , linguistics , philosophy , nursing
Developmental work towards a camera phone diagnostic platform applying localized surface plasmon resonance (LSPR) label-free sensing is presented. The application of spherical gold nanoparticles and nanorods are considered and assessed against ease of application, sensitivity, and practicality for a sensor for the detection of CCL2 (chemokine ligand 2). The sensitivity of the platform is compared with that of a commercial UV/Vis spectrometer. The sensitivity of the camera phone platform is found to be 30% less than that of the commercial system for an equivalent incubation time, but approaches that of the commercial system as incubation time increases. This suggests that the application of LSPR sensing on a portable camera phone devices may be a highly effective label-free approach for point-of-care use as a low-cost diagnostic sensing tool in environments where dedicated equipment is not available
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