Effects of Orally Administered Lactoferrin and Lactoperoxidase-Containing Tablets on Clinical and Bacteriological Profiles in Chronic Periodontitis Patients | Zendy

Eiju Shimizu | Zendy; Tetsuo Kobayashi | Zendy; Hiroyuki Wakabayashi | Zendy; Koji Yamauchi | Zendy; Keiji Iwatsuki | Zendy; Hiromasa Yoshie | Zendy

Open Access

Effects of Orally Administered Lactoferrin and Lactoperoxidase-Containing Tablets on Clinical and Bacteriological Profiles in Chronic Periodontitis Patients

Author(s) -

Eiju Shimizu,

Tetsuo Kobayashi,

Hiroyuki Wakabayashi,

Koji Yamauchi,

Keiji Iwatsuki,

Hiromasa Yoshie

Publication year - 2011

Publication title -

international journal of dentistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.61

H-Index - 33

eISSN - 1687-8736

pISSN - 1687-8728

DOI - 10.1155/2011/405139

Subject(s) - lactoperoxidase , lactoferrin , medicine , chronic periodontitis , periodontitis , dentistry , oral administration , chlorhexidine , gastroenterology , peroxidase , enzyme , chemistry , biochemistry

This study was undertaken to evaluate the effect of oral administration of lactoferrin (LF) and lactoperoxidase-(LPO-)containing tablet on periodontal condition. Seventy-two individuals with chronic periodontitis were randomly assigned to take either bovine LF and LPO-containing tablets (test group, n = 37) or control tablets (control group, n = 35) every day for 12 weeks. Periodontal parameters and levels of subgingival plaque bacteria, human and bovine LF, and endotoxin in gingival crevicular fluid (GCF) were evaluated at baseline, 1 week, 4 weeks, and 12 weeks. Significant differences were observed in GCF levels of bovine LF between the test and control groups throughout the study ( P < .05). However, clinical and bacteriological parameter values proved comparable between the two groups at 1 week to 12 weeks. Therefore, the effect of oral administration of LF and LPO-containing tablets might be weak on periodontal and bacteriological profile in this study.

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