Design and Synthesis of Small Molecules Based on a Substructural Analysis of the Histone Deacetylase Inhibitors TSA and SAHA | Zendy

Lynda Ekou | Zendy; Tchirioua Ekou | Zendy; Javier Eduardo GarcíaCastañeda | Zendy; Isabelle TranoyOpalinski | Zendy; Jean Pierre Gesson | Zendy

Open Access

Design and Synthesis of Small Molecules Based on a Substructural Analysis of the Histone Deacetylase Inhibitors TSA and SAHA

Author(s) -

Lynda Ekou,

Tchirioua Ekou,

Javier Eduardo GarcíaCastañeda,

Isabelle TranoyOpalinski,

Jean Pierre Gesson

Publication year - 2011

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2011/403129

Subject(s) - histone deacetylase , hydroxamic acid , chemistry , small molecule , histone , hdac1 , hdac11 , histone deacetylase 5 , histone deacetylase 2 , histone deacetylase inhibitor , vorinostat , cancer research , computational biology , biochemistry , biology , stereochemistry , gene

Inhibitors of histone deacetylases (HDACs) are patent inducers of differentiation and bear considerable potential as drugs for chemoprevention and treatment of cancer. In this paper, we have investigated three synthetic, inhibitors A1a,b, A2a. Analogue hybrid trichostatine A (TSA), suberoylanilide hydroxamic acid SAHA, in order to seek new histone deacetylases (HDACs) inhibitors

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