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Objectives . The aim of this study was to assess the effectiveness of SPECT/CT for volume measurements and to report a case illustrating the major impact of SPECT/CT in calculating the vascularized liver volume and dosimetry prior to injecting radiolabelled yttrium-90 microspheres (Therasphere).  Materials and Methods . This was a phantom study, involving volume measurements carried out by two operators using SPECT and SPECT/CT images. The percentage of error for each method was calculated, and interobserver reproducibility was evaluated. A treatment using Therasphere was planned in a patient with three hepatic arteries, and the quantitative analysis of SPECT/CT for this patient is provided.  Results . SPECT/CT volume measurements proved to be accurate (mean error <6% for volumes ≥16 cm 3 ) and reproductive (interobserver agreement = 0.9). In the case report,  99m Tc-MAA SPECT/CT identified a large liver volume, not  previously identified with angiography, which was shown to be  vascularized after selective MAA injection into an arterial  branch, resulting in a large modification in the activity of  Therasphere used.  Conclusions . MAA  SPECT/CT is accurate for vascularized liver volume measurements,  providing a valuable contribution to the therapeutic planning of  patients with complex hepatic vascularization.

international journal of molecular imaging

Utility of Quantitative <sup>99m</sup>Tc-MAA SPECT/CT for <sup>90</sup>yttrium-Labelled Microsphere Treatment Planning: Calculating Vascularized Hepatic Volume and Dosimetric Approach

Utility of Quantitative 99mTc-MAA SPECT/CT for 90yttrium-Labelled Microsphere Treatment Planning: Calculating Vascularized Hepatic Volume and Dosimetric Approach

Utility of Quantitative ^99mTc-MAA SPECT/CT for ⁹⁰yttrium-Labelled Microsphere Treatment Planning: Calculating Vascularized Hepatic Volume and Dosimetric Approach