Depressive Symptom Clusters and Neuropsychological Performance in Mild Alzheimer's and Cognitively Normal Elderly | Zendy

James Hall | Zendy; Sid E. O’Bryant | Zendy; Leigh Johnson | Zendy; Robert C. Barber | Zendy

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Depressive Symptom Clusters and Neuropsychological Performance in Mild Alzheimer's and Cognitively Normal Elderly

Author(s) -

James Hall,

Sid E. O’Bryant,

Leigh Johnson,

Robert C. Barber

Publication year - 2011

Publication title -

depression research and treatment

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.738

H-Index - 27

eISSN - 2090-133X

pISSN - 2090-1321

DOI - 10.1155/2011/396958

Subject(s) - apathy , neurocognitive , neuropsychology , medicine , geriatric depression scale , depression (economics) , dysphoria , cognition , clinical psychology , neuropsychological test , alzheimer's disease , disease , cohort , psychiatry , dementia , depressive symptoms , anxiety , economics , macroeconomics

Objectives . Determine the relationship between depressive symptom clusters and neuropsychological test performance in an elderly cohort of cognitively normal controls and mild Alzheimer's disease (AD). Design . Cross-sectional analysis. Setting . Four health science centers in Texas. Participants . 628 elderly individuals (272 diagnosed with mild AD and 356 controls) from ongoing longitudinal study of Alzheimer's disease. Measurements . Standard battery of neuropsychological tests and the 30-item Geriatric Depression Scale with regressions model generated on GDS-30 subscale scores (dysphoria, apathy, meaninglessness and cognitive impairment) as predictors and neuropsychological tests as outcome variables. Follow-up analyses by gender were conducted. Results . For AD, all symptom clusters were related to specific neurocognitive domains; among controls apathy and cognitive impairment were significantly related to neuropsychological functioning. The relationship between performance and symptom clusters was significantly different for males and females in each group. Conclusion . Findings suggest the need to examine disease status and gender when considering the impact of depressive symptoms on cognition.

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