Open AccessDNA Binding and Antitumor Activity of α-Diimineplatinum(II) and Palladium(II) Dithiocarbamate Complexes
Author(s) -
Hassan MansouriTorshizi,
Maryam Saeidifar,
Fatemeh Khosravi,
Adeleh Divsalar,
Ali Akbar Saboury,
Fatemeh Hassani
Publication year - 2011
Publication title -
bioinorganic chemistry and applications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.865
H-Index - 35
eISSN - 1565-3633
pISSN - 1687-479X
DOI - 10.1155/2011/394506
Subject(s) - dithiocarbamate , chemistry , palladium , dna , combinatorial chemistry , microbiology and biotechnology , stereochemistry , biochemistry , organic chemistry , catalysis , biology
The two water-soluble designed platinum(II) complex, [Pt(Oct-dtc)(bpy)]NO 3 (Oct-dtc = Octyldithiocarbamate and bpy = 2,2′ -bipyridine) and palladium(II) complex, [Pd(Oct-dtc)(bpy)]NO 3 , have been synthesized and characterized by elemental analyses, molar conductivity measurements, IR, 1 H NMR, and electronic spectra studies. Studies of antitumor activity of these complexes against human cell tumor lines (K562) have been carried out. They show Ic 50 values lower than that of cisplatin. The complexes have been investigated for their interaction with calf thymus DNA (CT-DNA) by utilizing the electronic absorption spectroscopy, fluorescence spectra, and ethidium bromide displacement and gel filtration techniques. Both of these water-soluble complexes bound cooperatively and intercalatively to the CT-DNA at very low concentrations. Several binding and thermodynamic parameters are also described.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom