Clinical Considerations ofBRCA1- andBRCA2-Mutation Carriers: A Review | Zendy

Olga Bougie | Zendy; Johanne I. Weberpals | Zendy

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Clinical Considerations ofBRCA1- andBRCA2-Mutation Carriers: A Review

Author(s) -

Olga Bougie,

Johanne I. Weberpals

Publication year - 2011

Publication title -

international journal of surgical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 22

eISSN - 2090-1410

pISSN - 2090-1402

DOI - 10.1155/2011/374012

Subject(s) - mutation , computer science , medicine , computational biology , bioinformatics , genetics , biology , gene

Individuals who carry an inherited mutation in the breast cancer 1 ( BRCA1 ) and BRCA2 genes have a significant risk of developing breast and ovarian cancer over the course of their lifetime. As a result, there are important considerations for the clinician in the counseling, followup and management of mutation carriers. This review outlines salient aspects in the approach to patients at high risk of developing breast and ovarian cancer, including criteria for genetic testing, screening guidelines, surgical prophylaxis, and chemoprevention.

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