Synthesis, Antimicrobial, and Anticoagulant Activities of 2-(Arylsulfonyl)indane-1,3-diones | Zendy

M. Jeyachandran | Zendy; Penugonda Ramesh | Zendy

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Synthesis, Antimicrobial, and Anticoagulant Activities of 2-(Arylsulfonyl)indane-1,3-diones

Author(s) -

M. Jeyachandran,

Penugonda Ramesh

Publication year - 2011

Publication title -

organic chemistry international

Language(s) - English

Resource type - Journals

eISSN - 2090-2018

pISSN - 2090-200X

DOI - 10.1155/2011/360810

Subject(s) - indane , antimicrobial , chemistry , knoevenagel condensation , phthalic anhydride , telithromycin , piperidine , pyridine , organic chemistry , medicinal chemistry , antibacterial agent , biochemistry , antibiotics , catalysis

2-(Arylsulfonyl)indane-1,3-diones, earlier synthesized by Claisen condensation involving diethyl phthalate and aryl methyl sulphones, are found to be potent blood anticoagulants. In search of improved analogs of 2-(arylsulfonyl)indane-1,3-dione, we have synthesized them (7 a-f) by a different route involving Knoevenagel reaction between phthalic anhydride and arylsulfonylacetates in the presence of pyridine-piperidine medium for the first time. The synthesized 2-(arylsulfonyl)indane-1,3-diones were evaluated for antimicrobial and anticoagulant activities and all of them registered significant activity

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