Tumor Necrosis Factor-Alpha Gene Promoter −308G/A and −238G/A Polymorphisms in Mexican Patients with Type 2 Diabetes Mellitus | Zendy

Juan Manuel GuzmánFlores | Zendy; José Francisco MuñozValle | Zendy; José SánchezCorona | Zendy; José G. Cobián | Zendy; Leopoldo Medina-Carrillo | Zendy; Alejandra Guadalupe Garcı́a-Zapién | Zendy; Edhit G. Cruz-Quevedo | Zendy; Silvia Esperanza Flores-Martí­nez | Zendy

Open Access

Tumor Necrosis Factor-Alpha Gene Promoter −308G/A and −238G/A Polymorphisms in Mexican Patients with Type 2 Diabetes Mellitus

Author(s) -

Juan Manuel GuzmánFlores,

José Francisco MuñozValle,

José SánchezCorona,

José G. Cobián,

Leopoldo Medina-Carrillo,

Alejandra Guadalupe Garcı́a-Zapién,

Edhit G. Cruz-Quevedo,

Silvia Esperanza Flores-Martínez

Publication year - 2011

Publication title -

disease markers

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.912

H-Index - 66

eISSN - 1875-8630

pISSN - 0278-0240

DOI - 10.1155/2011/360312

Subject(s) - haplotype , allele , tumor necrosis factor alpha , type 2 diabetes mellitus , promoter , gene , allele frequency , biology , diabetes mellitus , medicine , genetics , immunology , gastroenterology , endocrinology , gene expression

The association between some Tumor necrosis factor-alpha (TNF- α ) promoter polymorphisms and Type 2 diabetes mellitus (T2DM) remains controversial. Ethnic differences may play a role in these conflicting results. The aim of this study was to investigate the association between −308G/A and −238G/A polymorphisms located in the promoter region of the TNF- α gene and T2DM in Mexican mestizo patients. Nine hundred four individuals (259 patients with T2DM and 645 controls) were genotyped for the −308G/A and −238G/A polymorphisms by PCR—RFLP. We found that the −238A allele increased the risk of developing T2DM in Mexican patients (OR = 1.57, 95% CI: 1.07–2.29; p = 0.018). Moreover, we found that the frequency of the GA haplotype (created by the −308G and −238A alleles) was significantly increased in patients with T2DM when compared with controls (OR = 1.56, 95% CI: 1.05–2.31; p = 0.026). Our results suggest that the −238G/A polymorphism and a specific haplotype (GA) are genetic risk factors for the development of T2DM in Mexican population.

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