Epitope Analysis of Cerebrospinal Fluid IgG in Japanese Multiple Sclerosis Patients Using Phage Display Method | Zendy

Juichi Fujimori | Zendy; Ichiro Nakashima | Zendy; Kazuo Fujihara | Zendy; Tatsuro Misu | Zendy; Shigeru Sato | Zendy; Yasuto Itoyama | Zendy

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Epitope Analysis of Cerebrospinal Fluid IgG in Japanese Multiple Sclerosis Patients Using Phage Display Method

Author(s) -

Juichi Fujimori,

Ichiro Nakashima,

Kazuo Fujihara,

Tatsuro Misu,

Shigeru Sato,

Yasuto Itoyama

Publication year - 2011

Publication title -

multiple sclerosis international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.125

H-Index - 6

eISSN - 2090-2662

pISSN - 2090-2654

DOI - 10.1155/2011/353417

Subject(s) - multiple sclerosis , cerebrospinal fluid , herpes simplex virus , epitope , medicine , antigen , virus , virology , antibody , phage display , peptide , immunology , biology , pathology , biochemistry

To investigate the antigen recognized by cerebrospinal fluid (CSF) high affinity IgG in patients with multiple sclerosis (MS), the phage display method was applied to the CSF from 15 MS and 10 control patients. Peptide sequences recognized by MS and control CSF IgG were individual specific, and no common motif was found. Peptide sequences frequently showed homology to various kinds of amino acid sequences of ubiquitous viruses such as epstein barr virus (EBV) and herpes simplex virus (HSV), although the frequency was not specific to MS patients. MS CSF IgG may recognize various types of ubiquitous viral antigen and may be increased by a bystander response.

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