Gene by Sex Interaction for Measures of Obesity in the Framingham Heart Study | Zendy

Ashlee M. Benjamin | Zendy; Sunil Suchindran | Zendy; Kaela Pearce | Zendy; Jennifer Rowell | Zendy; Lillian F. Lien | Zendy; John R. Guyton | Zendy; Jeanette McCarthy | Zendy

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Gene by Sex Interaction for Measures of Obesity in the Framingham Heart Study

Author(s) -

Ashlee M. Benjamin,

Sunil Suchindran,

Kaela Pearce,

Jennifer Rowell,

Lillian F. Lien,

John R. Guyton,

Jeanette McCarthy

Publication year - 2010

Publication title -

journal of obesity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.756

H-Index - 53

eISSN - 2090-0716

pISSN - 2090-0708

DOI - 10.1155/2011/329038

Subject(s) - framingham heart study , obesity , locus (genetics) , offspring , medicine , genotype , genome wide association study , framingham risk score , genetics , cohort , gene , biology , disease , single nucleotide polymorphism , pregnancy

Obesity is an increasingly prevalent and severe health concern with a substantial heritable component and marked sex differences. We sought to determine if the effect of genetic variants also differed by sex by performing a genome-wide association study modeling the effect of genotype-by-sex interaction on obesity phenotypes. Genotype data from individuals in the Framingham Heart Study Offspring cohort were analyzed across five exams. Although no variants showed genome-wide significant gene-by-sex interaction in any individual exam, four polymorphisms displayed a consistent BMI association (P-values .00186 to .00010) across all five exams. These variants were clustered downstream of LYPLAL1, which encodes a lipase/esterase expressed in adipose tissue, a locus previously identified as having sex-specific effects on central obesity. Primary effects in males were in the opposite direction from females and were replicated in Framingham Generation 3. Our data support a sex-influenced association between genetic variation at the LYPLAL1 locus and obesity-related traits

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