A Malignant Gastrointestinal Stromal Tumor of the Gallbladder Immunoreactive for PDGFRA and Negative for CD 117 Antigen (c-KIT) | Zendy

Athanasios Petrou | Zendy; Pari Alexandrou | Zendy; Alexandros Papalambros | Zendy; Angelica A. Saetta | Zendy; Paraskevi C. Fragkou | Zendy; Michalis Kontos | Zendy; Nicholas Brennan | Zendy; Antonio Manzelli | Zendy; Kostantinos Bramis | Zendy; Evangelos Felekouras | Zendy

Open Access

A Malignant Gastrointestinal Stromal Tumor of the Gallbladder Immunoreactive for PDGFRA and Negative for CD 117 Antigen (c-KIT)

Author(s) -

Athanasios Petrou,

Pari Alexandrou,

Alexandros Papalambros,

Angelica A. Saetta,

Paraskevi C. Fragkou,

Michalis Kontos,

Nicholas Brennan,

Antonio Manzelli,

Kostantinos Bramis,

Evangelos Felekouras

Publication year - 2011

Publication title -

hpb surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.561

H-Index - 26

eISSN - 1607-8462

pISSN - 0894-8569

DOI - 10.1155/2011/327192

Subject(s) - pdgfra , medicine , stromal cell , stromal tumor , gist , gallbladder , pathology , antigen , gastrointestinal tract , gastroenterology , immunology

Gastrointestinal stromal tumors (GISTs) compose the largest category of well-recognized nonepithelial neoplasms of the gastrointestinal tract (GI). GISTs of the gallbladder are extremely rare tumors. Only four malignant, two benign and one GIST-like tumor of the gall bladder have ever been described. The four malignant GISTs were all positive for CD 117 antigen (c-kit). We present for the first time a malignant gastrointestinal stromal tumor of the gallbladder, immunoreactive for platelet-derived growth factor receptor alpha (PDGFRA) and negative for CD 117 antigen (c-KIT).

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