Associations of Plasma Phospholipid Omega-6 and Omega-3 Polyunsaturated Fatty Acid Levels and MRI Measures of Cardiovascular Structure and Function: The Multiethnic Study of Atherosclerosis | Zendy

Jennifer S. Anderson | Zendy; Jennifer A. Nettleton | Zendy; W. Gregory Hundley | Zendy; Michael Y. Tsai | Zendy; Lyn M. Steffen | Zendy; Rozenn N. Lemaître | Zendy; David S. Siscovick | Zendy; João A.C. Lima | Zendy; Martin R. Prince | Zendy; David M. Herrington | Zendy

Open Access

Associations of Plasma Phospholipid Omega-6 and Omega-3 Polyunsaturated Fatty Acid Levels and MRI Measures of Cardiovascular Structure and Function: The Multiethnic Study of Atherosclerosis

Author(s) -

Jennifer S. Anderson,

Jennifer A. Nettleton,

W. Gregory Hundley,

Michael Y. Tsai,

Lyn M. Steffen,

Rozenn N. Lemaître,

David S. Siscovick,

João A.C. Lima,

Martin R. Prince,

David M. Herrington

Publication year - 2011

Publication title -

journal of nutrition and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.789

H-Index - 42

eISSN - 2090-0732

pISSN - 2090-0724

DOI - 10.1155/2011/315134

Subject(s) - docosahexaenoic acid , arachidonic acid , eicosapentaenoic acid , medicine , algorithm , linoleic acid , fatty acid , polyunsaturated fatty acid , chemistry , biochemistry , computer science , enzyme

Background . The association between plasma omega-6 fatty acids and cardiovascular disease (CVD) is unclear, and discrepancy remains concerning the cardiovascular benefit of the omega-3 fatty acid alpha-linolenic acid. Methods . Associations of plasma phospholipid fatty acid levels (arachidonic acid, linoleic acid, eicosapentaenoic acid, docosahexaenoic acid (DHA), and alpha-linolenic acid) with cardiac magnetic resonance imaging measures of left ventricular (LV) mass, LV volume, ejection fraction, stroke volume, and aortic distensibility were investigated in 1,274 adults. Results . Results of multivariate analysis showed no statistically significant associations of plasma omega-6 or omega-3 levels with cardiac magnetic resonance imaging measures. Stratification by gender revealed a positive association between DHA and LV mass in women ( β = 1.89, P = 0.02; P interaction = 0.003) and a trend for a positive association between DHA and ejection fraction in men ( β = 0.009, P = 0.05; P interaction = 0.03). Conclusion . Additional research is warranted to clarify the effects of plasma DHA on cardiac structure and function in women versus men.

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