Congenital Cytomegalovirus Infection Manifesting as Neonatal Persistent Pulmonary Hypertension: Report of Two Cases | Zendy

E. Walter-Nicolet | Zendy; Magali Leblanc | Zendy; Marianne LeruezVille | Zendy; Philippe Hubert | Zendy; Delphine Mitanchez | Zendy

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Congenital Cytomegalovirus Infection Manifesting as Neonatal Persistent Pulmonary Hypertension: Report of Two Cases

Author(s) -

E. Walter-Nicolet,

Magali Leblanc,

Marianne LeruezVille,

Philippe Hubert,

Delphine Mitanchez

Publication year - 2011

Publication title -

pulmonary medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.528

H-Index - 30

eISSN - 2090-1836

pISSN - 2090-1844

DOI - 10.1155/2011/293285

Subject(s) - medicine , ganciclovir , persistent pulmonary hypertension , extracorporeal membrane oxygenation , pulmonary hypertension , cytomegalovirus , inotrope , hypoxemia , pediatrics , refractory (planetary science) , surgery , human immunodeficiency virus (hiv) , human cytomegalovirus , immunology , virus , herpesviridae , viral disease , physics , astrobiology

Various neonatal symptoms can lead to a diagnosis of congenital CMV infection. We report two cases of persistent pulmonary hypertension in relation with congenital CMV infection following maternal primary infection and reinfection, respectively. Both infants had severe refractory hypoxemia, requiring high-frequency ventilation, inhaled nitric oxide and inotropic support. One of them required extracorporeal membrane oxygenation for five days. Ganciclovir therapy was attempted in the two cases on day 12 postnatal. One of the infant died on day 15 postnatal. The other survived and is developing uneventfully at 15 months of age. Conclusion : Neonatal persistent pulmonary hypertension can be the consequence of congenital CMV infection. Intensive respiratory support and IV ganciclovir are indicated in case of life-threatening condition.

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