English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Objective . Systemic sclerosis (SSc) is a complex autoimmune disease in which interferons (IFNs) may play an essential role. We hypothesized that type I and III IFNs may be found in increased levels in patients and be responsible for SSc autoimmune status.  Methods . Type I and III IFN and ISG basal expression profiles were measured by qPCR using RNA from PBMCs of patients and controls .  Results . Type I IFNs are increased in SSc patients, while no induction of type III IFNs was detected. This induction cannot be related to IRF7, since no upregulation of this gene was seen on patients. Of the ISGs tested, 2′5′OAS levels were increased in patients, while 6–16 and MxA levels were not.  Conclusions . While there is no indication of type III IFN induction, increased levels of type I IFNs may lead to abnormal regulation of ISGs that can be responsible for immune system alterations described for SSc.

international journal of rheumatology

Basal Activation of Type I Interferons (Alpha2 and Beta) and<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msup><mml:mn mathvariant="bold">2</mml:mn><mml:mo mathvariant="bold">′</mml:mo></mml:msup><mml:msup><mml:mn mathvariant="bold">5</mml:mn><mml:mo mathvariant="bold">′</mml:mo></mml:msup></mml:mrow></mml:math>OAS Genes: Insights into Differential Expression Profiles of Interferon System Components in Systemic Sclerosis

Basal Activation of Type I Interferons (Alpha2 and Beta) and2′5′OAS Genes: Insights into Differential Expression Profiles of Interferon System Components in Systemic Sclerosis