Changes in the 24 h Rhythmicity of Liver PPARs and Peroxisomal Markers When Feeding Is Restricted to Two Daytime Hours | Zendy

Julieta Berenice Rivera-Zavala | Zendy; Adrian BáezRuíz | Zendy; Mauricio DíazMuñoz | Zendy

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Changes in the 24 h Rhythmicity of Liver PPARs and Peroxisomal Markers When Feeding Is Restricted to Two Daytime Hours

Author(s) -

Julieta Berenice Rivera-Zavala,

Adrian BáezRuíz,

Mauricio DíazMuñoz

Publication year - 2011

Publication title -

ppar research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.164

H-Index - 49

eISSN - 1687-4765

pISSN - 1687-4757

DOI - 10.1155/2011/261584

Subject(s) - medicine , peroxisome , endocrinology , peroxisome proliferator activated receptor , catalase , metabolism , chemistry , biology , receptor , oxidative stress

Restricted feeding (RF) during daytime is associated with anticipatory activity before feeding, marked hyperphagia after mealtime, adjustments in hepatic metabolism, and the expression of a food-entrained oscillator (FEO). 24 h rhythmicity of liver PPAR α , β , and γ , peroxisomal markers (PMP70, AOX, and catalase), and free fatty acids (FFAs) during RF was evaluated. The effect of fasting-refeeding was also studied. Results showed (1) higher levels of FFA before feeding, (2) a shift of PPAR α and PPAR γ before and of PPAR β peaks after feeding, (3) an increase in peroxisomal markers, (4) a shift of PMP70 and AOX peaks before feeding, and of maximal catalase activity in the dark period, (5) changes in the fasting-refeeding response, and (6) high correlations (>0.9) of serum corticosterone with PPAR α and PPAR γ and of PMP70 with PPAR β . In conclusion, 24 h rhythmicity of FFA, liver PPARs, and peroxisomal markers are biochemical adaptations associated with daytime RF and FEO expression.

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