Synthesis and Antibacterial Activities of Some Schiff Bases

Schiff bases p-hydroxybenzylidene-2-carboxyaniline, p-nitrobenz-ylidene-2-carboxyaniline, p-(N, N-dimethyl)aminobenzylidene-2-carboxyaniline, N-(4-hydroxybezylidene)-benzene-1,2-diamine, N--(4-nitrobezylidene)benzene-1,2-diamine, N-(4-(N, N-dimethylaminobezylidene)benzene-1,2-diamine, N-(4-(N,N-dimethylamino)benzylidene)naphthalen-1-amine,N-(4-nitrobenzylidene)naphthalen-1-amine,N--(4-chlorobenzylidene)naphthalen-1-amine,sodium-4-(4-(N,N-dimethyl amino)benzylideneamino)naphthalene-1-sulfonate,sodium -4-(4-nitrobenzylidene-amino)naphthalene-1-sulfonate and sodium-4-(4-chlorobenzylideneamino) naphthalene-1-sulfonate obtained by condensation of aniline and naphthyl-amine derivatives with some aromatic aldehydes were characterized by physical and spectral methods. The biological activity of these products were as antibacterial agents against three species of human pathogenic bacteria such as Escherichia coli, Staphylococcus aureus and Klebsiella sp. Nearly 50% of these compounds showed reasonable activity against the bacterial species investigated and we found that the antibacterial activity is dependent on the molecular structure of the compounds