Metastasis Update: Human Prostate Carcinoma Invasion via Tubulogenesis | Zendy

Raymond B. Nagle | Zendy; Anne E. Cress | Zendy

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Metastasis Update: Human Prostate Carcinoma Invasion via Tubulogenesis

Author(s) -

Raymond B. Nagle,

Anne E. Cress

Publication year - 2011

Publication title -

prostate cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.377

H-Index - 11

eISSN - 2090-3111

pISSN - 2090-312X

DOI - 10.1155/2011/249290

Subject(s) - metastasis , stromal cell , medicine , morphogenesis , prostate carcinoma , embryonic stem cell , prostate cancer , prostate , stroma , mesenchymal stem cell , carcinoma , cancer research , pathology , bioinformatics , cancer , biology , immunohistochemistry , gene , biochemistry

This paper proposes that human prostate carcinoma primarily invades as a cohesive cell collective through a mechanism similar to embryonic tubulogenesis, instead of the popular epithelial-mesenchymal transformation (EMT) model. Evidence supporting a tubulogenesis model is presented, along with suggestions for additional research. Additionally, observations documenting cell adhesion molecule changes in tissue and stromal components are reviewed, allowing for comparisons between the current branching morphogenesis models and the tubulogenesis model. Finally, the implications of this model on prevailing views of therapeutic and diagnostic strategies for aggressive prostatic disease are considered.

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