Monoclonal Gammopathy of Undetermined Significance (MGUS) in a Man with Fragile X-associated Tremor/Ataxia Syndrome | Zendy

Tanjung Ayu Sumekar | Zendy; Aneel A. Ashrani | Zendy; Tri Indah Winarni | Zendy; Randi J. Hagerman | Zendy

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Monoclonal Gammopathy of Undetermined Significance (MGUS) in a Man with Fragile X-associated Tremor/Ataxia Syndrome

Author(s) -

Tanjung Ayu Sumekar,

Aneel A. Ashrani,

Tri Indah Winarni,

Randi J. Hagerman

Publication year - 2011

Publication title -

case reports in genetics

Language(s) - English

Resource type - Journals

eISSN - 2090-6544

pISSN - 2090-6552

DOI - 10.1155/2011/143132

Subject(s) - monoclonal gammopathy of undetermined significance , medicine , ataxia , multiple myeloma , pathology , disease , monoclonal , immunology , psychiatry , monoclonal antibody , antibody

We report the clinical presentation and laboratory findings of a 69-year-old man with fragile X-associated tremor ataxia syndrome (FXTAS), a progressive neurodegenerative disorder, who was noted to have monoclonal gammopathy of undetermined significance (MGUS), a plasma cell proliferative disorder and a precursor disease of multiple myeloma. Both MGUS and FXTAS are associated with microRNA (miRNA) dysregulation. We speculate that individuals with FXTAS may be predisposed to MGUS and further studies are warranted regarding this association.

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