Transforming Growth Factor-Beta Signaling in the Neural Stem Cell Niche: A Therapeutic Target for Huntington's Disease | Zendy

Mahesh Kandasamy | Zendy; Ralf Reilmann | Zendy; Jürgen Winkler | Zendy; Ulrich Bogdahn | Zendy; Ludwig Aigner | Zendy

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Transforming Growth Factor-Beta Signaling in the Neural Stem Cell Niche: A Therapeutic Target for Huntington's Disease

Author(s) -

Mahesh Kandasamy,

Ralf Reilmann,

Jürgen Winkler,

Ulrich Bogdahn,

Ludwig Aigner

Publication year - 2011

Publication title -

neurology research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.365

H-Index - 31

eISSN - 2090-1852

pISSN - 2090-1860

DOI - 10.1155/2011/124256

Subject(s) - huntington's disease , neural stem cell , neuroscience , stem cell , niche , hippocampal formation , disease , stem cell niche , medicine , mechanism (biology) , biology , microbiology and biotechnology , pathology , progenitor cell , ecology , philosophy , epistemology

The neural stem cell niches possess the regenerative capacity to generate new functional neurons in the adult brain, suggesting the possibility of endogenous neuronal replacement after injury or disease. Huntington disease (HD) is a neurodegenerative disease and characterized by neuronal loss in the basal ganglia, leading to motor, cognitive, and psychological disabilities. Apparently, in order to make use of the neural stem cell niche as a therapeutic concept for repair strategies in HD, it is important to understand the cellular and molecular composition of the neural stem cell niche under such neurodegenerative conditions. This paper mainly discusses the current knowledge on the regulation of the hippocampal neural stem cell niche in the adult brain and by which mechanism it might be compromised in the case of HD.

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