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We investigated the antiplasmodial properties of crude extracts from  Carica papaya  leaves to trace the activity through bioassay-guided fractionation. The greatest antiplasmodial activity was observed in the ethyl acetate crude extract.  C. papaya  showed a high selectivity for  P. falciparum  against CHO cells with a selectivity index of 249.25 and 185.37 in the chloroquine-sensitive D10 and chloroquine-resistant DD2 strains, respectively.  Carica papaya  ethyl acetate extract was subjected to bioassay-guided fractionation to ascertain the most active fraction, which was purified and identified using high-pressure liquid chromatography (HPLC) and GC-MS (Gas chromatography-Mass spectrometry) methods. Linoleic and linolenic acids identified from the ethyl acetate fraction showed IC 50  of 6.88   μ  g/ml and 3.58   μ  g/ml, respectively. The study demonstrated greater antiplasmodial activity of the crude ethyl acetate extract of  Carica papaya  leaves with an IC 50  of 2.96 ± 0.14   μ  g/ml when compared to the activity of the fractions and isolated compounds.

Antiplasmodial Properties and Bioassay-Guided Fractionation of Ethyl Acetate Extracts fromCarica papayaLeaves