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In this study, we investigated in groups of female BALB/c mice injected with  Crotalus durissus terrificus  venom ( Cdt ) the renal function based on creatinine clearance, percentage of fractional excretion cytokines and histological examination of renal tissue.  Cdt  caused renal alterations that induced proteinuria during the initial hours post-venom and reduced creatinine clearance 15 min. up to 2 hours post-venom administration. In urine from mice injected with  Cdt  induced a decrease in IL-4 levels. More pronounced increments of IL-5, IL-6 and IFN-  γ   were observed after 15 and 30 min, respectively. The highest levels of TNF and IL-10 were observed at 1 and 4 hs, respectively. The ratios of pro- and anti-inflammatory cytokines in animals injected with  Cdt , which may be manifested in the inflammatory status during the envenoming. In groups of animals treated with  Cdt  were observed a decreasing in creatinine clearance and its effect on glomerular filtration rate was accompanied by decreased fractional excretion of cytokines and morphologic disturbances. This loss of change selectively in envenomation could thus explain why the relatively excretion of cytokines is reduced while of total proteins increases. In conclusion the fractional excretion of cytokines is significantly reduced in mice injected with  Cdt , despite proteinuria.

Inflammatory Mediators Release in Urine from Mice Injected withCrotalus durissus terrificusVenom