Synthesis, Characterization, DNA Binding, and Photocleavage Activity of Oxorhenium (V) Complexes withα-Diimine and Quinoxaline Ligands | Zendy

Christiana A. Mitsopoulou | Zendy; Constantinos E. Dagas | Zendy

Open Access

Synthesis, Characterization, DNA Binding, and Photocleavage Activity of Oxorhenium (V) Complexes withα-Diimine and Quinoxaline Ligands

Author(s) -

Christiana A. Mitsopoulou,

Constantinos E. Dagas

Publication year - 2010

Publication title -

bioinorganic chemistry and applications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.865

H-Index - 35

eISSN - 1565-3633

pISSN - 1687-479X

DOI - 10.1155/2010/973742

Subject(s) - chemistry , quinoxaline , cyclic voltammetry , dna , cleavage (geology) , intercalation (chemistry) , diimine , crystallography , stereochemistry , organic chemistry , biochemistry , electrode , materials science , electrochemistry , fracture (geology) , catalysis , composite material

The complex [ReOCl 3 pq] ( 1 ) (where pq = 2-(2′pyridyl)quinoxaline) has been synthesized and fully characterized by UV-Vis, FTIR, 1 and 2D NMR, and cyclic voltammetry (CV). The DNA-binding properties of the complex 1 as well as of the compounds [ReOCl 3 bpy] ( 2 ), [ReOCl 3 phen] ( 3 ), and pq ( 4 ) were investigated by UV-spectrophotometric (melting curves), CV (cyclic voltammetry), and viscosity measurements. Experimental data suggest that complex 1 intercalates into the DNA base pairs. Upon irradiation, complex 1 was found to promote the cleavage of plasmid pBR 322 DNA from supercoiled form I to nicked form II. The mechanism of the DNA cleavage by complex 1 was also investigated.

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