Cytokines and Other Mediators in Alopecia Areata | Zendy

Stamatios Gregoriou | Zendy; Dafni Papafragkaki | Zendy; George Kontochristopoulos | Zendy; Εfstathios Rallis | Zendy; D. Kalogeromitros | Zendy; Dimitris Rigopoulos | Zendy

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Cytokines and Other Mediators in Alopecia Areata

Author(s) -

Stamatios Gregoriou,

Dafni Papafragkaki,

George Kontochristopoulos,

Εfstathios Rallis,

D. Kalogeromitros,

Dimitris Rigopoulos

Publication year - 2010

Publication title -

mediators of inflammation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.37

H-Index - 97

eISSN - 1466-1861

pISSN - 0962-9351

DOI - 10.1155/2010/928030

Subject(s) - alopecia areata , immunology , pathogenesis , disease , medicine , b cell activating factor , autoimmune disease , cytokine , etiology , antibody , pathology , b cell

Alopecia areata, a disease of the hair follicles with multifactorial etiology and a strong component of autoimmune origin, has been extensively studied as far as the role of several cytokines is concerned. So far, IFN- γ , interleukins, TNF- α , are cytokines that are well known to play a major role in the pathogenesis of the disease, while several studies have shown that many more pathways exist. Among them, MIG, IP-10, BAFF, HLA antigens, MIG, as well as stress hormones are implicated in disease onset and activity. Within the scope of this paper, the authors attempt to shed light upon the complexity of alopecia areata underlying mechanisms and indicate pathways that may suggest future treatments.

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