Digital Ischemia in Scleroderma Spectrum of Diseases | Zendy

Elena Schiopu | Zendy; Ann Impens | Zendy; Kristine Phillips | Zendy

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Digital Ischemia in Scleroderma Spectrum of Diseases

Author(s) -

Elena Schiopu,

Ann Impens,

Kristine Phillips

Publication year - 2010

Publication title -

international journal of rheumatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.8

H-Index - 33

eISSN - 1687-9279

pISSN - 1687-9260

DOI - 10.1155/2010/923743

Subject(s) - scleroderma (fungus) , medicine , fibrosis , etiology , pathogenesis , extracellular matrix , ischemia , disease , endothelial dysfunction , thrombosis , pathology , autoimmune disease , cardiology , biology , inoculation , microbiology and biotechnology

Systemic Sclerosis (Scleroderma, SSc) is a disease of unknown etiology characterized by widespread vasculopathy and extracellular matrix deposition leading to fibrosis and autoimmune processes. Digital ischemia (digital ulcers (DUs)) is the hallmark of SSc-related vasculopathy and is characterized by endothelial dysfunction leading to intimal proliferation and thrombosis. It happens frequently (30% of the patients each year) and it is associated with significant morbidity. This paper summarizes the current information regarding pathogenesis, definitions, management, and exploratory therapies in DUs associated with SSc.

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