Photodynamic Therapy with the Silicon Phthalocyanine Pc 4 Induces Apoptosis in Mycosis Fungoides and Sezary Syndrome | Zendy

Minh Lam | Zendy; Yoojin Lee | Zendy; Min Deng | Zendy; Andrew H. Hsia | Zendy; Kelly A. Morrissey | Zendy; Yan Chun-lin | Zendy; Kashif Azzizudin | Zendy; Nancy L. Oleinick | Zendy; Thomas S. McCormick | Zendy; Kevin D. Cooper | Zendy; Elma D. Baron | Zendy

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Photodynamic Therapy with the Silicon Phthalocyanine Pc 4 Induces Apoptosis in Mycosis Fungoides and Sezary Syndrome

Author(s) -

Minh Lam,

Yoojin Lee,

Min Deng,

Andrew H. Hsia,

Kelly A. Morrissey,

Yan Chun-lin,

Kashif Azzizudin,

Nancy L. Oleinick,

Thomas S. McCormick,

Kevin D. Cooper,

Elma D. Baron

Publication year - 2010

Publication title -

advances in hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.371

H-Index - 31

eISSN - 1687-9112

pISSN - 1687-9104

DOI - 10.1155/2010/896161

Subject(s) - mycosis fungoides , photodynamic therapy , cutaneous t cell lymphoma , medicine , lymphoma , photosensitizer , pathology , cancer research , apoptosis , peripheral t cell lymphoma , cutaneous lymphoma , jurkat cells , immunology , t cell , chemistry , immune system , biochemistry , organic chemistry

Our current focus on the effects of Photodynamic Therapy (PDT) using silicon phthalocyanine Pc 4 photosensitizer on malignant T lymphocytes arose due to preclinical observations that Jurkat cells, common surrogate for human T cell lymphoma, were more sensitive to Pc 4-PDT-induced killing than epidermoid carcinoma A431 cells. Mycosis fungoides (MF) as well as Sezary syndrome (SS) are variants of cutaneous T-cell lymphoma (CTCL) in which malignant T-cells invade the epidermis. In this study, we investigated the cytotoxicity of Pc 4-PDT in peripheral blood cells obtained from patients with SS and in skin biopsies of patients with MF. Our data suggest that Pc 4-PDT preferentially induces apoptosis of CD4 + CD7 − malignant T-lymphocytes in the blood relative to CD11b + monocytes and nonmalignant T-cells. In vivo Pc 4-PDT of MF skin also photodamages the antiapoptotic protein Bcl-2.

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