Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus | Zendy

Inge A. M. van den Oever | Zendy; Hennie G. Raterman | Zendy; Michael T. Nurmohamed | Zendy; Suat Şimşek | Zendy

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Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus

Author(s) -

Inge A. M. van den Oever,

Hennie G. Raterman,

Michael T. Nurmohamed,

Suat Şimşek

Publication year - 2010

Publication title -

mediators of inflammation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.37

H-Index - 97

eISSN - 1466-1861

pISSN - 0962-9351

DOI - 10.1155/2010/792393

Subject(s) - endothelial dysfunction , diabetes mellitus , dyslipidemia , medicine , pathogenesis , inflammation , disease , apoptosis , type 2 diabetes mellitus , vascular disease , bioinformatics , immunology , endocrinology , biology , biochemistry

Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, including apoptosis of microvascular cells, ultimately leading to diabetes related complications. This review summarizes the mechanisms by which the interplay between endothelial dysfunction, inflammation, and apoptosis may cause (micro)vascular damage in patients with diabetes mellitus.

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