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Obese leptin-deficient  ob/ob  mice exhibit a low-grade chronic inflammation together with a low muscle mass.  Our aim was to analyze the changes in muscle expression levels of genes related to oxidative stress and inflammatory responses in leptin deficiency and to identify the effect of  in vivo  leptin administration.  Ob/ob  mice were divided in three groups as follows: control  ob/ob , leptin-treated  ob/ob  (1 mg/kg/d) and leptin pair-fed  ob/ob  mice. Gastrocnemius weight was lower in control  ob/ob  than in wild type mice ( P  < .01) exhibiting an increase after leptin treatment compared to control and pair-fed ( P  < .01)  ob/ob  animals. Thiobarbituric acid reactive substances, markers of oxidative stress, were higher in serum ( P  < .01) and gastrocnemius ( P  = .05) of control  ob/ob  than in wild type mice and were significantly decreased ( P  < .01) by leptin treatment. Leptin deficiency altered the expression of 1,546 genes, while leptin treatment modified the regulation of 1,127 genes with 86 of them being involved in oxidative stress, immune defense and inflammatory response. Leptin administration decreased the high expression of  Crybb1, Hspb3, Hspb7, Mt4, Cat, Rbm9, Serpinc1  and  Serpinb1a  observed in control  ob/ob  mice, indicating that it improves inflammation and muscle loss.

mediators of inflammation

Leptin Administration Downregulates the Increased Expression Levels of Genes Related to Oxidative Stress and Inflammation in the Skeletal Muscle of<i>ob/ob</i>Mice

Leptin Administration Downregulates the Increased Expression Levels of Genes Related to Oxidative Stress and Inflammation in the Skeletal Muscle ofob/obMice