B-Cell Pathology in Juvenile Idiopathic Arthritis | Zendy

Verena Wiegering | Zendy; Hermann Girschick | Zendy; Henner Morbach | Zendy

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B-Cell Pathology in Juvenile Idiopathic Arthritis

Author(s) -

Verena Wiegering,

Hermann Girschick,

Henner Morbach

Publication year - 2010

Publication title -

arthritis

Language(s) - English

Resource type - Journals

eISSN - 2090-1984

pISSN - 2090-1992

DOI - 10.1155/2010/759868

Subject(s) - medicine , arthritis , context (archaeology) , rheumatoid arthritis , juvenile rheumatoid arthritis , immunology , juvenile , pathogenesis , b cell , antibody , biology , paleontology , genetics

Juvenile Idiopathic Arthritis (JIA) is the most common cause of chronic arthritis in childhood and adolescents and encompasses a heterogeneous group of different diseases. Due to the promising results of B-cell depleting therapies in rheumatoid arthritis the role of B-cells in autoimmune diseases has to be discussed in a new context. Additionally, experiments in mouse models have shed new light on the antibody-independent role of B-cells in the development of autoimmune diseases. In this review we will discuss the importance of B-cells in the pathogenesis of JIA appraising the question for an immunological basis of B-cell targeted therapy in JIA.

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