A validated direct spectrofluorimetric method for quantification of mirtazapine in human whole blood | Zendy

Balraj Saini | Zendy; Manjula Kaushal | Zendy; Gulshan Bansal | Zendy

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A validated direct spectrofluorimetric method for quantification of mirtazapine in human whole blood

Author(s) -

Balraj Saini,

Manjula Kaushal,

Gulshan Bansal

Publication year - 2010

Publication title -

spectroscopy an international journal

Language(s) - English

Resource type - Journals

eISSN - 1875-922X

pISSN - 0712-4813

DOI - 10.1155/2010/731489

Subject(s) - mirtazapine , chromatography , detection limit , human blood , chemistry , whole blood , medicine , surgery , physiology , hippocampus , antidepressant

A spectrofluorimetric method for estimation of mirtazapine in human whole blood was developed and validated. The recovery efficiency of the processing method was 95–98%. The analytical method was linear over drug concentration of 10–200 ng/ml. The limit of quantification was 10 ng/ml. The method was precise with %RSD for intra-day and inter-day precision being <3.0 and 1.5, respectively. Excellent recoveries (97.87–99.69%) were achieved during accuracy studies. The method was robust to small changes in processing method and instrumental parameters. The present method can be employed for direct fluorimetric determination of mirtazapine in human whole blood during clinical studies.

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