Heavy Metal-Induced Oxidative DNA Damage in Earthworms: A Review | Zendy

Takeshi Hirano | Zendy; Kazuyoshi Tamae | Zendy

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Heavy Metal-Induced Oxidative DNA Damage in Earthworms: A Review

Author(s) -

Takeshi Hirano,

Kazuyoshi Tamae

Publication year - 2010

Publication title -

applied and environmental soil science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.431

H-Index - 23

eISSN - 1687-7675

pISSN - 1687-7667

DOI - 10.1155/2010/726946

Subject(s) - earthworm , bioaccumulation , cadmium , metal , environmental chemistry , oligochaeta (plant) , chemistry , contamination , biology , ecology , organic chemistry

Earthworms can be used as a bio-indicator of metal contamination in soil, Earlier reports claimed the bioaccumulation of heavy metals in earthworm tissues, while the metal-induced mutagenicity reared in contaminated soils for long duration. But we examined the metal-induced mutagenicity in earthworms reared in metal containing culture beddings. In this experiment we observed the generation of 8-oxoguanine (8-oxo-Gua) in earthworms exposed to cadmium and nickel in soil. 8-oxo-Gua is a major premutagenic form of oxidative DNA damage that induces GC-to-TA point mutations, leading to carcinogenesis

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