Leukocyte Counts, Myeloperoxidase, and Pregnancy-Associated Plasma Protein A as Biomarkers for Cardiovascular Disease: Towards a Multi-Biomarker Approach | Zendy

Marc B. I. Lobbes | Zendy; M. Eline Kooi | Zendy; Esther Lutgens | Zendy; A. W. Ruiters | Zendy; Valéria Lima Passos | Zendy; Simon H. Braat | Zendy; Mat Rousch | Zendy; Hugo Ten Cate | Zendy; Jos M. A. van Engelshoven | Zendy; Mat J.A.P. Daemen | Zendy; Sylvia Heeneman | Zendy

Open Access

Leukocyte Counts, Myeloperoxidase, and Pregnancy-Associated Plasma Protein A as Biomarkers for Cardiovascular Disease: Towards a Multi-Biomarker Approach

Author(s) -

Marc B. I. Lobbes,

M. Eline Kooi,

Esther Lutgens,

A. W. Ruiters,

Valéria Lima Passos,

Simon H. Braat,

Mat Rousch,

Hugo Ten Cate,

Jos M. A. van Engelshoven,

Mat J.A.P. Daemen,

Sylvia Heeneman

Publication year - 2010

Publication title -

international journal of vascular medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.411

H-Index - 27

eISSN - 2090-2832

pISSN - 2090-2824

DOI - 10.1155/2010/726207

Subject(s) - medicine , myeloperoxidase , fibrinogen , myocardial infarction , unstable angina , biomarker , pregnancy associated plasma protein a , cardiology , acute coronary syndrome , disease , gastroenterology , immunology , inflammation , pregnancy , biochemistry , chemistry , fetus , first trimester , biology , genetics

We evaluated leukocyte counts and levels of CRP, fibrinogen, MPO, and PAPP-A in patients with stable and unstable angina pectoris, acute myocardial infarction, and healthy controls. All biomarkers were analyzed again after 6 months. Leukocyte counts and concentrations of fibrinogen, CRP, MPO, and PAPP-A were significantly increased in patients with acute myocardial infarction. Leukocyte counts and concentrations of MPO were significantly increased in patients with unstable angina pectoris compared with controls. After 6 months, leukocyte counts and MPO concentrations were still increased in patients with acute myocardial infarction when compared to controls. Discriminant analysis showed that leukocyte counts, MPO, and PAPP-A concentrations classified study group designation for acute coronary events correctly in 83% of the cases. In conclusion, combined assessment of leukocyte counts, MPO, and PAPP-A was able to correctly classify acute coronary events, suggesting that this could be a promising panel for a multibiomarker approach to assess cardiovascular risk.

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